Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway
Abstract Background Liver surgery during the perioperative period often leads to a significant complication known as hepatic ischemia-reperfusion (I/R) injury.Hepatic I/R injury is linked to the innate immune response.The cGAS-STING pathway triggers the activation of innate immune through the detection of DNA within cells.Nevertheless, the precise