BLOCKADE OF THE MITOCHONDRIAL DNA RELEASE AMELIORATES HEPATIC ISCHEMIA-REPERFUSION INJURY THROUGH AVOIDING THE ACTIVATION OF CGAS-STING PATHWAY

Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway

Abstract Background Liver surgery during the perioperative period often leads to a significant complication known as hepatic ischemia-reperfusion (I/R) injury.Hepatic I/R injury is linked to the innate immune response.The cGAS-STING pathway triggers the activation of innate immune through the detection of DNA within cells.Nevertheless, the precise

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Degenerated, Undifferentiated, Rearranged, Lost: High Variability of Sex Chromosomes in Geometridae (Lepidoptera) Identified by Sex Chromatin

Sex chromatin is a conspicuous body that occurs in polyploid nuclei of most lepidopteran females and consists of numerous copies of the W sex chromosome.It is also a cytogenetic tool used to rapidly assess the W chromosome presence in Lepidoptera.However, certain chromosomal features could Laptop Screen Cleaner disrupt the formation of sex chromati

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Ability of Arkansas LaKast and LaKast Hybrid Rice Bran to Reduce Salmonella Typhimurium in Chicken Cecal Incubations and Effects on Cecal Microbiota

The objective of the present study was to evaluate the prebiotic ability of Arkansas (AR) LaKast rice bran cultivars as a feed supplement to reduce Salmonella Typhimurium and other gut microbiota.An in vitro mixed anaerobic culture system was used to simulate conditions in the chicken ceca.Anaerobic cultures contained feed, cecal contents collected

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In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research.Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice.Using a 7-stage protocol, human iPSCs were differentiated into islet-like aggregates with a yield of in

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